Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System
Running, not enrolling · Not applicable
Conditions studied: Barrett Esophagus
In brief
To evaluate the efficacy and safety of the CryoBalloon Focal Ablation System for the treatment of previously-untreated ("treatment naïve") Barrett's Esophagus (BE)
Key facts
- Study ID
- NCT02514525
- Run by
- Pentax Medical
- People needed
- 150
- Starts
- 2016-03-01
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-01-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Low- or high-grade non-nodular, previously untreated ("treatment naïve") dysplastic BE, confirmed by histopathological analysis. If nodular BE or Intramuscosal Cancer (ImCA) is identified during patient screening, this may be treated with Endoscopic Mucosal Resection (EMR) ≥6 weeks prior to treatment under this protocol. If previous EMR was performed, follow-up endoscopy must be negative for nodular BE. Patients with ImCA must be at low risk for recurrence, confirmed by EMR pathology results negative for positive margin, poorly differentiated carcinoma, and lymphovascular invasion.
- BE length ≤6cm excluding visible BE islands, and Prague Classification C ≥0 / M ≥1
- Older than 18 years of age at time of consent
- Operable per institution's standards
- Provides written informed consent on the approved informed consent form
- Willing and able to comply with study requirements for follow-up
You may not qualify if…
- Non-dysplastic or indefinite for dysplasia BE, confirmed by histopathological analysis
- Esophageal stenosis/stricture preventing advancement of a therapeutic endoscope (patients may have the stenosis/stricture dilated and then be treated with CryoBalloon ablation under this protocol at a subsequent procedure ≥2 weeks later)
- Symptomatic untreated strictures
- Any endoscopically-visualized abnormalities such as ulcers, masses or nodules. Neoplastic nodules must first be treated with EMR ≥6 weeks prior to planned treatment under this protocol.
- History of esophageal cancer more extensive than T1a or not meeting criteria for low risk of recurrence (confirmed by EMR pathology results negative for positive margin, poorly differentiated carcinoma, and lymphovascular invasion)
- History of esophageal varices
- Large (>4cm) hiatal hernia
- Prior distal esophagectomy
- Any clinical or histological suspicion of esophageal adenocarcinoma invading into the submucosa by endoscopic mucosal resection (EMR), or confirmed T1a cancer with positive deep margin by EMR
- Active esophagitis grade B or higher
- Severe medical comorbidities precluding endoscopy
- Uncontrolled coagulopathy
- Pregnant or planning to become pregnant during period of study participation
- Patient refuses or is unable to provide written informed consent
- Life expectancy ≤3 years, as judged by the site investigator
- General poor health, multiple co-morbidities placing the patient at risk or otherwise unsuitable for trial participation
Where it is running
- UC Irvine — Orange, California, United States
- Sarasota Memorial Hospital — Sarasota, Florida, United States
- University of Chicago — Chicago, Illinois, United States
- John Hopkins — Baltimore, Maryland, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Northwell Health — Manhasset, New York, United States
- New York Presbyterian Hospital-Columbia University Medical Center — New York, New York, United States
- University of North Carolina School of Medicine — Chapel Hill, North Carolina, United States
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
- Geisinger Medical Center — Danville, Pennsylvania, United States
- Thomas Jefferson University — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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