Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Premenstrual Dysphoric Disorder

In brief

This research study will look at brain and symptom differences among women with severe premenstrual mood symptoms. One goal of this study is to look at the effects of taking a nasal spray containing oxytocin (a hormone made in the brain) on brain areas involved in emotion regulation while viewing pictures during a neuroimaging (fMRI) session. The investigators will also look at whether oxytocin improves premenstrual mood symptoms.

Key facts

Study ID

NCT02508103

Run by

University of North Carolina, Chapel Hill

People needed

10

Starts

2015-07-01

Expected to finish

2016-07-01

Last updated by the study team

2017-06-27

Who can join

Age: 18 and older, up to 52. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• In order to be eligible to enter this study, subjects will have met PMDD Study Entry Criteria in the diagnostic feeder study (IRB# 05-3000)
• 18 to 52 years of age
• Regular menstrual cycles
• Ability to give informed consent

You may not qualify if…

• current psychiatric diagnosis of substance abuse or claustrophobia (fear of closed places)
• pregnancy (based on urine pregnancy test) or breastfeeding
• use of psychiatric medication (e.g. for depression, anxiety), hormonal medication, other agents that alter mood or thinking, or street drugs
• any foreign iron or steel metal objects in the body, such as a pacemaker, shrapnel, metal plate, certain types of tattoos, or metal debris

Where it is running

• University of North Carolina — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.