Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology

Recruiting now

Conditions studied: Head and Neck Cancer, Squamous Cell Carcinoma (SCC) of the Oral Cavity

In brief

The purpose of this study is to get images (pictures) of oral lesions, which occur inside the mouth, before the patient's surgery using a special camera. These pictures will be used in our research to evaluate a new technology that uses a laser and takes pictures of the microscopic structure of tissue. The technology is called "reflectance confocal microscopy." We would like to compare what the camera sees to biopsies (pathology) of the same area. We will evaluate the pictures obtained from the patient to determine whether this technology may be useful in the future. We hope this technology can be used as a tool for early diagnosis of oral cancers and for guiding surgery.

Key facts

Study ID

NCT02507141

Run by

Memorial Sloan Kettering Cancer Center

People needed

140

Starts

2015-07-21

Expected to finish

2027-07-01

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with biopsy-proven oral SCC who are scheduled to undergo surgery in the MSK Head and Neck Service.
• Ability to sign informed consent.
• Age ≥ 18 years.

You may not qualify if…

• Cancer located on a site that may not be convenient or accessible for imaging with the current version of the RCM device (gingivobuccal region, back of the oral cavity, back of the tongue, floor of the mouth, deep under the tongue, etc.).
• Inability to give informed consent.

Where it is running

• Memorial Sloan Kettering Basking Ridge (consent only) — Basking Ridge, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Monmouth (consent only) — Middletown, New Jersey, United States (enrolling)
• Memorial Sloan Kettering West Harrison (consent only) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Nassau (consent only) — Uniondale, New York, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.