Potential Mechanism of Exercise Impairment in OSA
Completed
Conditions studied: Obstructive Sleep Apnea
In brief
Obstructive sleep apnea (OSA) is a common disorder with major cardiovascular sequelae. A recent study confirmed that OSA is associated with impaired exercise capacity and increasing OSA severity predicts worsening exercise capacity, which is a marker of potential increased cardiovascular risk. However, potential mechanisms of decreased exercise capacity caused by OSA remain unclear. Several pathophysiologic mechanisms of OSA have been proposed and investigators hypothesize that endothelial dysfunction leading to exercise-induced right ventricular dysfunction and associated pulmonary hypertension is the potential mechanism for impaired exercise capacity in OSA.
Key facts
- Study ID
- NCT02505594
- Run by
- University of California, San Diego
- People needed
- 29
- Starts
- 2015-07-01
- Expected to finish
- 2017-05-09
- Last updated by the study team
- 2018-01-05
Who can join
Age: 30 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- BMI < 30
- OSA group: diagnosis of untreated moderate-to-severe OSA (apnea-hypopnea index (AHI) ≥ 15 events/h).
- Control group: no OSA (AHI < 5 events/h).
You may not qualify if…
- Currently using Continuous Positive Airway Pressure (CPAP) or oral appliance treatment for OSA
- Uncontrolled cardiac co-morbidity, e.g. ischemic heart disease, heart failure, or valvular heart disease that would prevent exercise
- Uncontrolled pulmonary co-morbidity, e.g. asthma or chronic obstructive pulmonary disease (COPD)
- Comorbidities that may severely impair peripheral circulation, e.g. uncontrolled diabetes mellitus, or systemic scleroderma
- Neurological conditions limiting the ability to perform walking or cycling
- Orthopedic condition limiting the ability to perform walking or cycling
- Current smokers, alcohol (> 3 oz/day) or use of illicit drugs.
- Psychiatric disorder, other than mild and controlled depression; e.g. schizophrenia, bipolar disorder, major depression, panic or anxiety disorders.
- Pregnancy
Where it is running
- University of California, San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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