DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

Running, not enrolling

Conditions studied: Pulmonary Disease

In brief

The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well as new biomarkers discovered specifically in this clinical setting will be examined. Biomarkers that identify individuals at highest risk for being diagnosed with lung cancer prior to the appearance of concerning symptoms could increase the utility of lung cancer surveillance and the efficiency of lung cancer chemoprevention clinical trials. Achieving these goals would improve the detection and treatment of early stage and incipient lung cancer, while restricting the risk of these procedures to those individuals who currently exhibit the early molecular warning signs of impending disease.

Key facts

Study ID

NCT02504697

Run by

Boston University

People needed

665

Starts

2011-09-01

Expected to finish

2027-12-01

Last updated by the study team

2026-04-01

Who can join

Age: 50 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Diagnosis of lung cancer prior to the current assessment (that is, patients are eligible if first lung cancer diagnosis has been recently confirmed by bronchoscopic biopsy and is leading to resection surgery, but not if this is not a first diagnosis);
• Contraindications to nasal brushing or fiberoptic bronchoscopy, including: ulcerative nasal disease, hemodynamic instability, severe obstructive airway disease (i.e., disease severity does not allow for bronchoscopic procedures), unstable cardiac or pulmonary disease, as well as other comorbidities leading to inability to protect airway, or altered level of consciousness;
• Allergies to any local anesthetic that may be used to obtain biosamples in the study;
• Weight greater than that allowable by the CT scanner.

Where it is running

• Regents of the University of California LA (Los Angeles VA Healthcare System) — Los Angeles, California, United States
• University of California Los Angeles Medical Center — Los Angeles, California, United States
• Naval Medical Center San Diego — San Diego, California, United States
• Denver Research Institute — Denver, Colorado, United States
• Walter Reed National Military Medical Center — Bethesda, Maryland, United States
• Boston University Medical Center — Boston, Massachusetts, United States
• Boston VA Research Institute, Inc — Boston, Massachusetts, United States
• Health Research Inc. Roswell Park Division — Buffalo, New York, United States
• Trustees of University of Pennsylvania (Philadelphia VA Medical Center) — Philadelphia, Pennsylvania, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Veterans Research Foundation of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Middle Tennessee Research Institute (Vanderbilt University) — Nashville, Tennessee, United States
• Dallas VA Research Corporation — Dallas, Texas, United States
• San Antonio Military Medical Center — San Antonio, Texas, United States
• Naval Medical Center Portsmouth — Portsmouth, Virginia, United States

Full record on ClinicalTrials.gov

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