Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes

Completed · Phase 4

Conditions studied: Type 1 Diabetes, Diabetic Nephropathy, Diabetic Kidney Disease

In brief

The purpose of this study is to determine whether alkalinization of urine uric acid by 2 doses of sodium bicarbonate (1950mg) over 24-hours reduces precipitation and crystallization of urine uric acid over in adults with type 1 diabetes.

Key facts

Study ID

NCT02502071

Run by

University of Colorado, Denver

People needed

45

Starts

2017-01-01

Expected to finish

2017-08-01

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (aged 18-45 years) with type 1 diabetes
• Participants must be able to be fasting prior to study visit and give informed consent.

You may not qualify if…

• Non-type 1 diabetes
• History of eGFR <60 ml/min/1.73m2 or microalbuminuria or greater
• History of hypocalcemia or at risk of hypocalcemia
• Taking allopurinol or uric acid altering medications
• Ketogenic diet
• Ketonuria
• Taking phosphorus binders (e.g. sevelamer)
• Pregnant or breastfeeding
• Taking the following medications which may interact with sodium bicarbonate (e.g. phentermine, pseudoephedrine, antifungal medication, cephalosporin antibiotics [e.g. Keflex], tetracycline antibiotics [e.g. doxycycline], steroids or lithium)
• Taking SGLT-2 inhibitors
• Taking blood pressure medications

Where it is running

• Barbara Davis Center for Diabetes — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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