The Lean Living Study

Completed · Not applicable

Conditions studied: Overweight and Obesity

In brief

This study investigates whether walnuts help to promote weight loss, associated with increased meal satiety and satisfaction, in 100 overweight and obese men and women who are participating in a 6-month behavioral weight loss intervention. Participants will be randomly assigned to a walnut-enriched reduced-calorie diet or a standard reduced-calorie diet. Body weight, risk factors for cardiovascular disease, and self-reported feelings relevant to satiety and appetite will be measured at baseline and 3- and 6-month follow-up. Also, the response of gastrointestinal tract hormones following meals with or without walnuts will be measured in a subset of study participants (n=20). Results from this study will contribute to understanding the role of nuts in weight control, including further knowledge of the mechanisms, and will expand knowledge of how nuts in the diet may contribute to the prevention and management of obesity.

Key facts

Study ID

NCT02501889

Run by

University of California, San Diego

People needed

100

Starts

2015-08-01

Expected to finish

2017-06-01

Last updated by the study team

2017-10-26

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• aged 21 years and older
• BMI >27.0 kg/m2 and <40 kg/m2
• non-smoker
• willing and able to participate in clinic visits, group sessions, telephone, and internet communications at specified intervals
• able to provide data through questionnaires and by telephone
• willing to maintain contact with the investigators for 6 months
• willing to allow blood collections
• no known allergy to tree nuts
• capable of performing a simple test for assessing cardiopulmonary fitness

You may not qualify if…

• inability to participate in physical activity because of severe disability
• a history or presence of a comorbid diseases for which diet modification and increased physical activity may be contraindicated
• smoker
• self-reported pregnancy or breastfeeding or planning a pregnancy within the next year
• currently actively involved in another diet intervention study or organized weight loss program
• a history or presence of a significant psychiatric disorder or any other condition that, in the investigator's judgement, would interfere with participation in the trial

Where it is running

• UC San Diego — La Jolla, California, United States

Full record on ClinicalTrials.gov

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