The Effect of Electronic Cigarette (ECIG) Liquid Vehicles on ECIG Acute Effects
Completed · Phase 1
Conditions studied: Nicotine Exposure, Nicotine Withdrawal Suppression
In brief
This study examines the acute effects in ECIG users of the two primary vehicles in ECIG liquids, propylene glycol and vegetable glycerin. Thirty experienced ECIG users will use an ECIG in five conditions that will differ only by the propylene glycol:vegetable glycerin ratio: 100:0, 70:30, 50:50, 30:70, and 0:100 (device voltage, heater resistance, liquid nicotine concentration, puff number, and interpuff interval all will be held constant). Plasma nicotine concentration, subjective effects, and puffing behaviors will be recorded in each condition.
Key facts
- Study ID
- NCT02500615
- Run by
- Virginia Commonwealth University
- People needed
- 41
- Starts
- 2016-07-01
- Expected to finish
- 2017-05-16
- Last updated by the study team
- 2018-05-07
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants must use ≥1 ml of ECIG solution daily
- Must use ECIG solution with a nicotine concentration ≥12 mg/ml
- Must have used an ECIG for ≥3 months
- Must be willing to abstain from nicotine and tobacco products for ≥12 hours prior to each session.
You may not qualify if…
- History of chronic disease or psychiatric condition
- Regular use of a prescription medication
- Marijuana use >10 and alcohol use >25 days in the past 30
- Any other illicit drug use (e.g., cocaine, opioids) in the past 30 days.
- Positive test for pregnancy (by urinalysis)
- Daily use of >5 conventional tobacco cigarettes
Where it is running
- Clinical Behavioral Pharmacology Laboratory — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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