A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Completed · Phase 1/Phase 2
Conditions studied: Lymphocytic Leukemia, Chronic, Lymphoma, Non Hodgkin
In brief
This is a Phase 1/2 dose-escalation study of BTCT4465A (Mosunetuzumab) administered as a single agent and in combination with atezolizumab in participants with relapsed or refractory B-cell NHL and CLL. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.
Key facts
- Study ID
- NCT02500407
- Run by
- Genentech, Inc.
- People needed
- 713
- Starts
- 2015-09-15
- Expected to finish
- 2025-09-01
- Last updated by the study team
- 2025-09-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California San Diego Moores Cancer Center — La Jolla, California, United States
- Sansum Medical Clinic, Inc. — Santa Barbara, California, United States
- Rocky Mountain Cancer Center — Denver, Colorado, United States
- Yale University School Of Medicine — New Haven, Connecticut, United States
- Hackensack University Medical Center — Hackensack, New Jersey, United States
- Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
- Memorial Sloan Kettering Cancer Center - Commack — Commack, New York, United States
- Memorial Sloan Kettering Cancer Center at Westchester — Harrison, New York, United States
- New York Uni Medical Center — New York, New York, United States
- Willamette Valley Cancer Insitute and Research Center — Springfield, Oregon, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- St Vincent's Hospital Sydney — Darlinghurst, New South Wales, Australia
- Icon Cancer Care South Brisbane — South Brisbane, Queensland, Australia
- Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
- Royal Adelaide Hospital — Adelaide, South Australia, Australia
- St. Vincent's Hospital Melbourne — Fitzroy, South Australia, Australia
- Royal Hobart Hospital — Hobart, Tasmania, Australia
- Monash Health Clinical Trial Pharmacy department — Clayton, Victoria, Australia
- The Perth Blood Institute — Nedlands, Western Australia, Australia
- Princess Margaret Hospital — Toronto, Ontario, Canada
- Jewish General Hospital — Montreal, Quebec, Canada
- Universitatsklinikum Koln — Cologne, Germany
- Universitätsklinikum Heidelberg — Heidelberg, Germany
- Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz — Mainz, Germany
Full record on ClinicalTrials.gov
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