Does Sweet Taste Potentiate Nicotine Cue Reactivity?

Completed · Phase 1

Conditions studied: Healthy

In brief

The investigators' aim is to test the prediction that sweet taste perception enhances the ability of nicotine to induce neural plastic changes in brain reward circuits to increase the saliency, liking and brain reactivity to the sight and vaporized flavor of electronic cigarettes (e-cigarettes).

Key facts

Study ID

NCT02499757

Run by

Yale University

People needed

15

Starts

2015-05-01

Expected to finish

2015-11-01

Last updated by the study team

2020-03-09

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• right handed
• non-daily smoker
• english speaking

You may not qualify if…

• serious or unstable medical illness (e.g., cancer);
• past or current history of alcoholism or consistent drug use;
• current and history of major psychiatric illness as defined by the DSM-IV criteria including eating disorders,
• medications that affect alertness (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, etc.) and any psychoactive drugs or anti-obesity agents;
• history of major head trauma with loss of consciousness;
• ongoing pregnancy;
• known taste or smell dysfunction;
• a diagnosis of diabetes;
• any known allergies or sensitivity, including to food, vapors or odors;
• pregnant or nursing women,
• history of metalworking, injury with shrapnel or metal slivers, and major surgery;
• history of pacemaker or neurostimulator implantation m) asthma, chronic obstructive pulmonary disease, bronchitis or any other lung disease.

Where it is running

• The John B Pierce Laboratory — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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