A Randomized, Double-Blind, Parallel-Group, 24-Week, Chronic-Dosing, Multi-Center Study to Assess the Efficacy and Safety of PT010, PT003, and PT009 Compared With Symbicort® Turbuhaler® (Kronos)

Completed · Phase 3

Conditions studied: COPD

In brief

Study to Assess the Efficacy and Safety of PT010, PT003, and PT009 Compared With Symbicort® Turbuhaler® in Subjects with Moderate to Very Severe Chronic Obstructive Pulmonary Disease.

Key facts

Study ID

NCT02497001

Run by

Pearl Therapeutics, Inc.

People needed

1902

Starts

2015-08-10

Expected to finish

2018-01-05

Last updated by the study team

2020-12-24

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Given their signed written informed consent to participate.
• Non-child bearing potential (ie, physiologically incapable of becoming pregnant, including any female who is 2 years post-menopausal); or Child bearing potential, has a negative serum pregnancy test at Visit 1, and agrees to acceptable contraceptive methods used consistently and correctly for the duration of the study.
• Subjects with an established clinical history of COPD as defined by the American Thoracic Society (ATS)/European Respiratory Society (ERS), or other local applicable guidelines.
• Current or former smokers with a history of at least 10 pack-years of cigarette smoking.
• Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) ratio must be <0.70 and FEV1 must be <80% predicted normal value calculated using NHANES III reference equations (or reference norms applicable to other regions).
• Required COPD maintenance therapy:
• All Subjects must have been on two or more inhaled maintenance therapies for the management of their COPD for at least 6 weeks prior to Screening. Scheduled SABA and/or scheduled SAMA are considered inhaled maintenance therapies
• Please refer to the study protocol for the complete inclusion criteria list.

You may not qualify if…

• Significant diseases or conditions other than COPD, which, in the opinion of the Investigator, may put the subject at risk because of participation in the study or may influence either the results of the study or the subject's ability to participate in the study.
• Women who are pregnant or lactating, or are planning to become pregnant during the course of the study, or women of childbearing potential who are not using an acceptable method of contraception.
• Subjects, who in the opinion of the Investigator, have a current diagnosis of asthma.
• Subjects who have been hospitalized due to poorly controlled COPD within 3 months prior to Visit 1 (Screening) or during the Screening Period
• Subjects who have poorly controlled COPD, defined as acute worsening of COPD that requires treatment with oral corticosteroids or antibiotics within 6 weeks prior to Visit 1 (Screening) or during the Screening Period
• Immune suppression or severe neurological disorders affecting control of the upper airway or other risk factors that in the opinion of the Investigator would put the subject at substantial risk of pneumonia.
• Subjects with a diagnosis of narrow angle glaucoma, who, in the opinion of the Investigator, have not been adequately treated.
• Subjects who have a history of hypersensitivity to β2-agonists, budesonide or any other corticosteroid components, glycopyrronium or other muscarinic anticholinergics, or any other component of the IMPs.
• Please refer to the study protocol for the complete inclusion criteria list.

Where it is running

• Research Site — Jasper, Alabama, United States
• Research Site — Peoria, Arizona, United States
• Research Site — Phoenix, Arizona, United States
• Research Site — Fullerton, California, United States
• Research Site — Gold River, California, United States
• Research Site — Poway, California, United States
• Research Site — Rolling Hills Estates, California, United States
• Research Site — Sacramento, California, United States
• Research Site — Clearwater, Florida, United States
• Research Site — Miami, Florida, United States
• Research Site — Miami, Florida, United States
• Research Site — Ormond Beach, Florida, United States
• Research Site — Pensacola, Florida, United States
• Research Site — Tamarac, Florida, United States
• Research Site — Tampa, Florida, United States
• Research Site — Winter Park, Florida, United States
• Research Site — Dacula, Georgia, United States
• Research Site — Norcross, Georgia, United States
• Research Site — Rincon, Georgia, United States
• Research Site — Edina, Minnesota, United States
• Research Site — Minneapolis, Minnesota, United States
• Research Site — Minneapolis, Minnesota, United States
• Research Site — Woodbury, Minnesota, United States
• Research Site — Saint Charles, Missouri, United States
• Research Site — Andalusia, Alabama, United States

Full record on ClinicalTrials.gov

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