Telemedicine for Women With Anhedonia in Bipolar and Unipolar Disorder
Completed · Not applicable
Conditions studied: Depression, Bipolar Disorder, Anhedonia
In brief
Anhedonia, characterized as (a) the diminished motivation to participate in activities, and/or (b) diminished enjoyment of a pleasurable activity are common symptoms among women diagnosed with mood disorders. This trial aims to test three treatments adapted to reduce anhedonia. The investigators will compare three treatment groups, specifically, two doses of Behavioral Activation treatment for anhedonia (i.e., 12 weeks vs. 8 weeks of BA) with an active comparator treatment, Bipolar Disorder Collaborative Care (12 weeks of BDCC). BA is a psychotherapy approach that helps participants to identify and modify environmental sources of their depression. BDCC is a supportive care approach that educates participants to optimize their medication initiation or their existing medication regimen. The time frame for this study will be between 12-14 weeks. Specifically, participants will be evaluated and enrolled within one week, then received up to 12 weeks of treatment (tracked through this time) and then complete two evaluations (one at week 8) and another at the end of treatment (an expected average of 12-14 weeks after enrolling into treatment). Primary analyses aim to compare the dose-mechanism change in BA relative to a standard medication optimizing protocol, BDCC. The secondary analyses are to evaluate individual differences in stated patient preferences for treatment, and group differences in treatment effect on anhedonia, side effects, and quality of life.
Key facts
- Study ID
- NCT02494050
- Run by
- Northwestern University
- People needed
- 17
- Starts
- 2015-06-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2016-09-30
Who can join
Age: 21 and older, up to 65. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Currently experiencing a score ≥ 20 on a clinician-administered scale of anhedonia
- Currently experiencing two or more symptoms of depression with bipolar disorder either Type I or II (one of these symptoms should be anhedonia) OR
- Currently experiencing two or more symptoms of unipolar depression, without current psychotic features (one of these symptoms should be anhedonia)
- Currently on a medication for a mood disorder
- Proficiency in English
- Able to provide informed consent
You may not qualify if…
- Current psychosis (schizoaffective, schizophreniform, delusional disorder)
- Current suicide risk sufficient to preclude treatment on an outpatient basis
- Severe, unstable concurrent psychiatric conditions likely to require hospitalization within six months (ex. hazardous substance use evidenced by a score > 10 on the Alcohol Use Disorders Identification Test or > 2 on the Drug Use Disorders identification Test)
- Current incarcerated or on probation due to criminal allegations
- Currently pregnant
- Cognitive impairment
- Those living in the United States on a VISA
- Those currently in psychotherapy
Where it is running
- Northwestern University — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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