Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation

Withdrawn before enrolling · Not applicable

Conditions studied: Obesity

In brief

The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation. The investigators hypothesized that a titrated level of PEEP ("Titrated-PEEP") during SBT will keep the lung recruited, maintain oxygenation, and decrease the work of breathing resulting in successful ventilator liberation. In addition, post-extubation the investigators hypothesize that these patients will require noninvasive ventilatory support in the form of CPAP at the level of "titrated-PEEP" used during the SBT.

Key facts

Study ID

NCT02492113

Run by

Massachusetts General Hospital

People needed

0

Starts

2015-11-01

Expected to finish

2025-11-24

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intubated and mechanically ventilated;
• Weaning from mechanical ventilation;
• BMI ≥ 35 kg/m2 with waist circumference > 88 cm for women; waist circumference > 102 cm for men.
• A well functioning arterial line.

You may not qualify if…

• Known presence of esophageal varices
• Recent esophageal trauma or surgery
• Severe thrombocytopenia (PTL ≤ 5,000/mm3)
• Severe coagulopathy (INR ≥ 4)
• Presence of pneumothorax
• Pregnancy
• Pacemaker and/or internal cardiac defibrillator

Where it is running

• Massachussets General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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