Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases
Stopped early · Phase 2 · Has a placebo group
Conditions studied: Radionecrosis, Brain Metastases
In brief
This randomized phase II study aims to investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms and less treatment-induced symptoms compared with standard corticosteroid therapy for patients with symptomatic brain radionecrosis following radiosurgery. It is hypothesized that the addition of bevacizumab to standard care corticosteroids will reduce treatment-induced toxicities and improve neurologic impairments in patients with brain radionecrosis following radiosurgery for brain metastases.
Key facts
- Study ID
- NCT02490878
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 19
- Starts
- 2016-04-01
- Expected to finish
- 2022-12-15
- Last updated by the study team
- 2023-03-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Anchorage Radiation Therapy Center — Anchorage, Alaska, United States
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- PCR Oncology — Arroyo Grande, California, United States
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Beebe Medical Center — Lewes, Delaware, United States
- Delaware Clinical and Laboratory Physicians PA — Newark, Delaware, United States
- Helen F Graham Cancer Center — Newark, Delaware, United States
- Medical Oncology Hematology Consultants PA — Newark, Delaware, United States
- Regional Hematology and Oncology PA — Newark, Delaware, United States
- Christiana Care Health System-Christiana Hospital — Newark, Delaware, United States
- Beebe Health Campus — Rehoboth Beach, Delaware, United States
- Nanticoke Memorial Hospital — Seaford, Delaware, United States
- Christiana Care Health System-Wilmington Hospital — Wilmington, Delaware, United States
- Boca Raton Regional Hospital — Boca Raton, Florida, United States
- Halifax Health Medical Center-Centers for Oncology — Daytona Beach, Florida, United States
- Baptist MD Anderson Cancer Center — Jacksonville, Florida, United States
- Mayo Clinic in Florida — Jacksonville, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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