Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia

Completed · Not applicable

Conditions studied: Spinocerebellar Ataxia

In brief

The purpose of this research study is to investigate how the brain and motor behavior changes both in individuals with spinocerebellar ataxia and healthy individuals, and to assess whether a therapeutic intervention reduces levels of uncoordinated movement and improves motor function in spinocerebellar ataxia (SCA).

Key facts

Study ID

NCT02488031

Run by

University of Florida

People needed

19

Starts

2016-03-01

Expected to finish

2019-01-17

Last updated by the study team

2019-05-13

Who can join

Age: 21 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DNA diagnosis of SCA1, SCA3, or SCA6
• phenotype consistent with the DNA diagnosis
• ability to walk 7 meters
• the age of 21-85 years
• capable of providing informed consent and complying with the trial procedures

You may not qualify if…

• Known recessive, X-linked or mitochondrial ataxias or any other type of ataxia
• Concomitant disorder(s) that affect ataxia measures used in this study
• Cognitive status on the Montreal Cognitive Assessment < 24
• Patients who have any type of implanted electrical device (such as a cardiac pacemaker or a neurostimulator), or a certain type of metallic clip in their body (i.e., an aneurysm clip in the brain), and are not eligible for participation in the MRI portion of the study
• Individuals who are claustrophobic
• Women who are or might be pregnant and nursing mothers
• Individuals with psychiatric disorders or dementia, along with other neurological and orthopedic problems that impair hand movements and walking

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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