Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery

Completed · Not applicable

Conditions studied: Pain, Postoperative

In brief

This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery. All patients will receive a standardized spinal anesthetic for operative anesthesia and will be randomized into one of three groups: (group 1) 1 gram IV acetaminophen every 8 hours for three doses, (group 2) 1 gram oral acetaminophen every 8 hours for three doses, or (group 3) no acetaminophen. This will be a randomized, open label study.

Key facts

Study ID

NCT02487303

Run by

Medical University of South Carolina

People needed

148

Starts

2015-03-17

Expected to finish

2017-07-27

Last updated by the study team

2018-12-05

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Parturients 18 years
• Elective Cesarean delivery
• Spinal anesthesia
• Able to consent to the study and participate in the follow-up.

You may not qualify if…

• Weight under 50 kgs
• Allergy to acetaminophen
• General anesthesia
• Urgent or emergent cases
• Bleeding diathesis or other coagulopathy
• G6PD deficiency
• Liver disease
• Substance abuse or dependence
• HELLP syndrome
• Thrombocytopenia or platelet dysfunction
• History or active gastrointestinal bleeding
• Acute kidney injury or chronic renal insufficiency
• Contraindication/refusal to spinal anesthesia
• Chronic pain
• Chronic narcotic use
• Illicit drug use
• Allergy to any study related medications.

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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