Amantadine to Speed Awakening After Cardiac Arrest

Completed · Phase 2 · Has a placebo group

Conditions studied: Coma, Heart Arrest, Anoxia

In brief

This study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation. Half of the participants will receive amantadine and the other will receive placebo.

Key facts

Study ID

NCT02486211

Run by

Jon Rittenberger, MD

People needed

14

Starts

2015-09-01

Expected to finish

2018-06-30

Last updated by the study team

2019-12-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Non traumatic cardiac arrest
• Age 18 and older
• Defibrillation and/or chest compressions by healthcare providers
• Return of spontaneous circulation

You may not qualify if…

• Written do not attempt resuscitation (DNAR) reported to providers before randomization
• Known prisoner or pregnancy
• Lack of motor response to pain and absent N20 response on somatosensory evoked potentials prior to randomization
• Initial CT demonstrating brain edema (defined as grey white ratio <1.2)
• Presence of malignant pattern on EEG at time of randomization
• Next of kin unwilling to provide supportive care for at least one week after enrollment
• Presently using other dopaminergic agent

Where it is running

• Main Medical Center — Portland, Maine, United States
• Beth Israel Deacconness — Boston, Massachusetts, United States
• UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania, United States
• UPMC Mercy Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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