Postoperative Nasal High Flow Versus Oxygen for Positive Airway Pressure Non-Compliance Sleep Apnea Patients
Completed · Not applicable
Conditions studied: Obstructive Sleep Apnea
In brief
The study aims to compare the efficacy of Nasal High Flow Therapy (NHF) with low-flow oxygen supplementation in improving postoperative intermittent desaturations. If so, this mode of therapy would provide a cost effective, relatively easy to implement, and better tolerated treatment to Continuous Positive Airway Pressure (CPAP) for oxygen stabilization.
Key facts
- Study ID
- NCT02485236
- Run by
- Mayo Clinic
- People needed
- 50
- Starts
- 2015-06-01
- Expected to finish
- 2017-05-28
- Last updated by the study team
- 2019-10-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Known diagnosis of obstructive sleep apnea by polysomnography (Apnea Hypopnea Index ≥ 5 events per hour) with recommendation of Continuous Positive Airway Pressure use.
- The patient declines use of Continuous Positive Airway Pressure for the upcoming elective surgery.
- The patient will require more than 48 hours of hospitalization.
- Informed consent obtained from patient or approved designate.
You may not qualify if…
- Predetermined need for Continuous Positive Airway Pressure post-operatively by surgical team.
- Body Mass Index ≥ 40.
- Patient with congestive heart failure and diagnosis of Cheyne- Stokes respiration or central apnea.
- Patients who are oxygen dependent due to moderate to severe Chronic Obstructive Pulmonary Disease (Available Forced Expiratory Volume at 1 second of < 50% predicted) or advanced interstitial lung disease.
- Preexisting chronic hypercapnia with known neuromuscular disease with respiratory involvement (e.g. Amyotrophic Lateral Sclerosis, myopathy).
- Severe anemia necessitating blood transfusion.
- Presence of tracheostomy.
- Naso-oral malformation or severe nasal septal defect.
- Presence of dementia or other diagnosed neurodegenerative disease.
- Non-English speakers
- Inability to provide informed consent.
Where it is running
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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