Pain Sensitization and Habituation in a Model of Experimentally-induced Insomnia Symptoms

Completed · Not applicable

Conditions studied: Sleep Control Condition, Insomnia Symptoms Induction Condition

In brief

The main purpose of this study is to learn about the effects of repeated exposure to sleep disruption (3 cycles of sleep disruption, each consisting of three days in a row where sleep is shortened and disrupted, followed by a single night of recovery sleep) on inflammation, mood, and pain processing (experiences/perceptions of pain). Purpose of this research project is to understand the mechanisms of how sleep disruption may change mood and the experience of pain. Understanding those mechanisms is important to develop interventions that may help to reduce the effects of sleep disruption on mood and pain.

Key facts

Study ID

NCT02484742

Run by

Beth Israel Deaconess Medical Center

People needed

23

Starts

2015-07-01

Expected to finish

2019-03-01

Last updated by the study team

2019-07-09

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Women and men between the ages 18-45 years.
• Body mass index (BMI) between 18.5 and 30 kg/m2.
• For female participants: regular menstrual cycles, no significant discomfort during pre-menses/menses.
• Good quantity/quality sleep
• Blood chemistry in the normal range.

You may not qualify if…

• - Active infection/disease.
• History of neurological, chronic pain, immune, cardiovascular, liver/kidney, or metabolic disorder.
• History of psychiatric disorders, including major depressive disorders, bipolar disorders, panic disorders, post-traumatic stress disorders (PTSD), thought disorders, and substance abuse/dependence disorders.
• Sleep disorders
• Pregnant/nursing.
• Regular medication use other than oral contraceptives.
• Donation of blood or platelets 3 month prior to or in-between study arms.

Where it is running

• BIDMC — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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