Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
Completed · Not applicable
Conditions studied: Prediabetes
In brief
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD. Greater intakes of dairy foods have been associated with a lower risk of CVD, but whether these effects occur directly or indirectly by displacing foods in the diet that might increase CVD risk is unclear. The health benefits of dairy on heart health are at least partly attributed to its ability to limit PPH and resulting PPH-mediated responses leading to vascular dysfunction. This provides rationale to further investigate dairy as a dietary strategy to reduce PPH and risk for CVD. The objective of this study is to define the extent to which dairy milk, and its whey and casein protein fractions, protect against postprandial vascular dysfunction by reducing oxidative stress responses that limit nitric oxide bioavailability to the vascular endothelium in adults with prediabetes.
Key facts
- Study ID
- NCT02482675
- Run by
- Ohio State University
- People needed
- 23
- Starts
- 2015-06-01
- Expected to finish
- 2018-02-01
- Last updated by the study team
- 2019-05-14
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- hemoglobin A1c 5.7-6.4%
- non-dietary supplement user
- no medications affecting vasodilation, inflammation, or energy metabolism
- no CVD
- nonsmokers
- individuals having blood pressure <140/90 mmHg and total cholesterol <240 mg/dL
You may not qualify if…
- unstable weight (±2 kg)
- vegetarian or dairy allergy
- alcohol intake >3 drinks/day or >10 drinks/week
- ≥7 hours/week of aerobic activity
Where it is running
- The Ohio State University — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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