A Study to Assess the Effect of Ticagrelor in Reducing the Number of Days With Pain in Patients With Sickle Cell Disease
Completed · Phase 2 · Has a placebo group
Conditions studied: Sickle Cell Disease
In brief
The purpose of this study is to determine whether ticagrelor is effective in reducing the number of days of pain, intensity of pain, and reducing the use of analgesics due to sickle cell disease
Key facts
- Study ID
- NCT02482298
- Run by
- AstraZeneca
- People needed
- 87
- Starts
- 2015-07-09
- Expected to finish
- 2016-11-16
- Last updated by the study team
- 2018-12-19
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Confirmed medical history or diagnosis of homozygous sickle cell (HbSS) or sickle beta-zero-thalassaemia (HbS/β0) by HPLC
- If treated with hydroxyurea, the dose must have been stable for 3 months
You may not qualify if…
- History of transient ischaemic attack or clinically overt cerebrovascular accident
- Moderate or severe hepatic impairment
- Treatment with chronic red blood cell transfusion therapy
- Pre-dominate cause of pain is not sickle cell disease related
- Chronic treatment with anticoagulants or antiplatelet drugs.
Where it is running
- Research Site — Miami, Florida, United States
- Research Site — Bethesda, Maryland, United States
- Research Site — Charleston, South Carolina, United States
- Research Site — Alexandria, Egypt
- Research Site — Cairo, Egypt
- Research Site — Cairo, Egypt
- Research Site — Bordeaux, France
- Research Site — Strasbourg, France
- Research Site — Verona, Italy
- Research Site — Kikuyu, Kenya
- Research Site — Kisian, Kenya
- Research Site — Nairobi, Kenya
- Research Site — Beirut, Lebanon
- Research Site — Beirut, Lebanon
- Research Site — Adana, Turkey (Türkiye)
- Research Site — Mersin, Turkey (Türkiye)
- Research Site — Van, Turkey (Türkiye)
- Research Site — Harrow, United Kingdom
- Research Site — London, United Kingdom
- Research Site — London, United Kingdom
Full record on ClinicalTrials.gov
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