A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi

Completed · Phase 2 · Has a placebo group

Conditions studied: Huntington's Disease

In brief

The purpose of this study is to evaluate the safety, tolerability, PK, and efficacy of Pepinemab in subjects with late prodromal and early manifest Huntington's disease.

Key facts

Study ID

NCT02481674

Run by

Vaccinex Inc.

People needed

301

Starts

2015-07-01

Expected to finish

2020-08-01

Last updated by the study team

2022-05-02

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of California, San Diego — La Jolla, California, United States
• University of California San Francisco — San Francisco, California, United States
• University of Colorado - Denver — Aurora, Colorado, United States
• Georgetown University — Washington D.C., District of Columbia, United States
• University of Florida Gainesville — Gainesville, Florida, United States
• Emory University School of Medicine — Atlanta, Georgia, United States
• Indiana University School of Medicine — Indianapolis, Indiana, United States
• University of Iowa — Iowa City, Iowa, United States
• University of Louisville — Louisville, Kentucky, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Massachusetts General Hospital — Charlestown, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Washington University — St Louis, Missouri, United States
• Columbia University — New York, New York, United States
• Columbia University — New York, New York, United States
• University of Rochester — Rochester, New York, United States
• Duke University Health Center — Durham, North Carolina, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• University of Toledo — Toledo, Ohio, United States
• Vanderbilt University — Nashville, Tennessee, United States
• University of Texas Houston Medical School — Houston, Texas, United States

Full record on ClinicalTrials.gov

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