The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth
Completed · Not applicable
Conditions studied: Pulpal Necrosis
In brief
In cases of permanent tooth avulsion, it is widely accepted that some necrosis always occurs after avulsion injury. If the pulp tissue does not revascularize or if endodontic therapy is not performed, the pulp space can become infected. Platelet rich fibrin (PRF) is a second generation platelet concentrate that allows the clinician to obtain fibrin membranes enriched with platelets and growth factors from an anticoagulant-free blood harvest. Clinical relevance of PRF and revascularization has been demonstrated in several case studies of avulsion. To date no human clinical trials have been performed evaluating the effectiveness of PRF on pulpal revascularization after reimplantation and its benefits in limiting inflammation. The following study consists of two phases: Phase 1: An in vitro model evaluating the effects of PRF in limiting inflammatory response of pdl cell cultures in the presence of an inflammatory mediators. Phase 2: An in vivo model utilizing mature teeth previously treatment planned for extraction, treating with PRF, reimplanting teeth and following for three to four months before extracting and performing histological analysis. If PRF is capable of promoting revascularization in mature teeth the potential benefits extend to limiting the need for endodontic therapy following mature tooth avulsion, potential for mature tooth transplantation in situations of congenitally missing teeth, and utilization of PRF in endodontic revascularization therapy.
Key facts
- Study ID
- NCT02477358
- Run by
- University of Nebraska
- People needed
- 18
- Starts
- 2014-09-29
- Expected to finish
- 2016-06-01
- Last updated by the study team
- 2023-10-04
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- any adult with single rooted vital teeth previously treatment planned for extraction to meet their prosthetic or orthodontic needs.
You may not qualify if…
- exclusion criteria will include: individuals with systemic illnesses that could compromise vascularity or healing,
- patients who are pregnant,
- or bisphosphonates.
Where it is running
- University of Nebraska, College of Dentistry — Lincoln, Nebraska, United States
Full record on ClinicalTrials.gov
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