A Pilot Trial of Curcumin Effects on Cognition in Schizophrenia
Stopped early · Not applicable · Has a placebo group
Conditions studied: Schizophrenia, Schizoaffective Disorder
In brief
This is an 8-week randomized, double-blind, placebo-controlled, parallel, fixed-dose pilot clinical trial of curcumin for the treatment of cognitive impairment in schizophrenia.The primary aim of this pilot trial is to provide an effect size estimate for the efficacy of curcumin in improving cognitive functioning in schizophrenia. Secondary goals are to determine the effect of curcumin over time on negative and positive symptoms, in association with inflammatory markers.
Key facts
- Study ID
- NCT02476708
- Run by
- Yale University
- People needed
- 12
- Starts
- 2016-02-11
- Expected to finish
- 2017-08-24
- Last updated by the study team
- 2018-01-23
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 - 65 years of age
- English speaking
- Diagnostic and Statistical Manual- IV diagnosis of schizophrenia or schizoaffective disorder based on Structured Clinical Interview for Diagnostic and Statistical Manual-IV (SCID)
- Symptomatic stability confirmed by clinical staff in the 8 weeks prior to the study
- No changes in antipsychotic medication within the last 8 weeks
- No change in antipsychotic dose in in last 4 weeks.
- Exclusion criteria are:
- Unable to provide informed consent
- Diagnostic and Statistical Manual-IV (DSM-IV) diagnosis of alcohol/substance dependence
- Recent history of gastrointestinal bleeding or ulceration
- Recent history of gallstones and/or bile duct obstruction
- Significant uncontrolled systemic illness (e.g. chronic renal failure, chronic liver disease, poorly controlled diabetes, poorly controlled congestive heart failure, chronic infectious disease, chronic autoimmune disease)
- Known intolerance to turmeric, curcumin, or curry
- Pregnancy or breast-feeding
- Current use of anti-platelet, anti-coagulant, glucocorticoid, immunosuppressants
- Daily use of non-steroidal anti-inflammatory use.
Where it is running
- Connecticut Mental Health Center — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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