Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease

Completed · Phase 4

Conditions studied: Chronic Kidney Disease, Pulmonary Embolism, Renal Artery Stenosis, Pulmonary Cancer

In brief

The purpose of this study is to show that the use of low volume iso-osmolar non-ionic radio contrast medium (30 cc) in a thoracic CT Scanning procedure in a selected group of patients with chronic kidney disease (CKD) will avoid contrast induced nephropathy (CIN) in comparison to a similar group of patients with CKD who receive no contrast medium..

Key facts

Study ID

NCT02476526

Run by

VA Greater Los Angeles Healthcare System

People needed

50

Starts

2008-09-01

Expected to finish

2017-11-20

Last updated by the study team

2017-11-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with documented stable Chronic Kidney Disease (CKD) defined as a stable eGFR 16-60 ml/min/m\^2 for ≥ 12 months; and
• Referred to CT scanning procedure to evaluate pulmonary embolism, pulmonary malignancy, acute aortic syndromes, or renal artery stenosis.

You may not qualify if…

• CKD Stages 1, 2 and 5
• Stage 3-4 congestive heart failure (CHF)
• Irregular supraventricular tachycardia
• Allergic to iodinated Radio Contrast Medium (RCM)
• Allergic to Mucomyst
• Pregnancy
• Evidence of acute renal failure (ARF)
• Serum bicarbonate either less than 20 meq/L or greater than 35 meq/L
• Hydration with a bicarbonate solution is contraindicated or considered unsafe by the subject's caring physicians

Where it is running

• VA Greater Los Angeles Healthcare System — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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