Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans

Completed · Not applicable · Has a placebo group

Conditions studied: Inflammation

In brief

The overall goal of the research study is to determine whether a high-fat meal causes postprandial (after meal) inflammation, and whether eating n-3 polyunsaturated fatty acids (PUFAs) or blueberries that are rich in anti-inflammatory polyphenols suppress the inflammation in healthy people.

Key facts

Study ID

NCT02472171

Run by

USDA, Western Human Nutrition Research Center

People needed

62

Starts

2015-06-01

Expected to finish

2017-11-01

Last updated by the study team

2018-10-30

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body Mass Index of 18-25 kg/m2
• Complete Blood Count (CBC) within normal limits
• Blood chemistry panel within normal limits

You may not qualify if…

• following a vegetarian diet
• smoke or use tobacco products
• consume more than one alcoholic beverage per day (defined as 1 oz. distilled liquor, 3 oz. wine, or 12 oz. beer)
• taking any cholesterol lowering
• taking blood pressure medication
• taking non-steroidal anti-inflammatory drugs (NSAIDS) more than once a week and for 3 days before each test day
• taking steroids for asthma or other inflammatory states
• taking thyroid-regulating drugs
• taking over-the-counter weight loss products
• allergies or sensitivities to foods or ingredients in the test meals, especially blueberries or DHA
• taking fish or algae oil or other dietary supplements and unwilling to stop the supplements for the duration of the study (multivitamin is OK)
• Women who are pregnant, lactating or planning a pregnancy
• fasting blood cholesterol greater than 240 mg/dL
• fasting blood triglyceride greater than 300mg/dL
• hemoglobin less than 11.5 mg/dL
• blood pressure greater than 140/90 mmHg
• metabolic diseases such as diabetes mellitus, hypothyroidism, kidney disease, liver disease, bleeding disorders, autoimmune diseases, other inflammatory disease, or cancer unless greater than 5 years remission

Where it is running

• USDA, ARS, Western Human Nutrition Research Center — Davis, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.