Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine Candidates

Recruiting now

Conditions studied: Malaria

In brief

Background: \- Malaria is a disease that affects many people in African countries. It is caused by germs that are spread by mosquito bites. It can be fatal if not diagnosed and treated right away. Children younger than 5 and pregnant women are most at risk to get malaria. Researchers want to create a vaccine that will prevent malaria infection during pregnancy. Objectives: \- To create a vaccine that will prevent malaria infection during pregnancy. To assess possible vaccines using in-vitro tests with parasites taken from pregnant women. Eligibility: \- Pregnant women ages 15-25 Design: * The study site is an area in Mali, West Africa. * Participants: * Will have blood drawn. * Will give consent for the blood sample to be used for future research. * May have a physical exam. * Participants who have malaria or anemia will get treatment.

Key facts

Study ID

NCT02471378

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

7476

Starts

2015-07-28

Expected to finish

2028-06-30

Last updated by the study team

2026-08-10

Who can join

Age: 15 and older, up to 25. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• Severe anemia defined as HGB<7 gr/dL, that may be worsened by 10 mL phlebotomy
• Conditions that in the judgment of the investigator could increase the risk to the volunteer
• Prior enrollment to the study during the same pregnancy

Where it is running

• Ouelessebougou Clinical Research Center — Bamako, Mali (enrolling)

Full record on ClinicalTrials.gov

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