Study of Venous Endothelial Cells in Rheumatoid Arthritis

Completed

Conditions studied: Rheumatoid Arthritis

In brief

Heart disease is the major contributor of early death in rheumatoid arthritis (RA) and is not influenced by traditional risk factors. Blood vessel dysfunction has been associated with heart disease and complications such as heart attack. The vessel dysfunction is thought to be mediated in part to inflammation. RA patients have evidence of vessel dysfunction seen on ultrasound that improves after medications are given. The purpose of this study is to evaluate patients with controlled or uncontrolled rheumatoid arthritis to determine if there is a difference in the protein expression in the cells that line the blood vessels compared to healthy people.

Key facts

Study ID

NCT02468986

Run by

University of Texas Southwestern Medical Center

People needed

56

Starts

2011-08-01

Expected to finish

2020-12-01

Last updated by the study team

2021-04-02

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Rheumatoid arthritis:
• Age 18-75 years
• Rheumatoid arthritis defined by 1987 American College of Rheumatology criteria
• Attending clinic at University of Texas Southwestern Aston Clinic for Rheumatology or Parkland Arthritis Clinic.
• Healthy controls:
• Age 18-75 years.

You may not qualify if…

• Rheumatoid arthritis:
• Insulin dependent diabetes
• Cardiovascular or Cerebrovascular disease
• Tobacco use in last 24 months
• Uncontrolled blood pressure
• Uncontrolled cholesterol
• Pregnant or nursing
• Prednisone greater than 10mg per day
• Stable methotrexate dose for less than 4 weeks
• Undergoing Infliximab infusions
• Healthy controls:
• Insulin dependent diabetes
• Cardiovascular or Cerebrovascular disease
• Tobacco use in last 24 months
• Uncontrolled high blood pressure
• Uncontrolled cholesterol
• Pregnant or nursing

Where it is running

• Parkland Memorial Hospital — Dallas, Texas, United States
• University of Texas Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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