Cognitive Dysfunction In Parkinson's
Completed · Not applicable · Has a placebo group
Conditions studied: Parkinson's
In brief
We hypothesize that reductions in gamma activity are a key mechanism underlying cognitive dysfunction in PD and that interventions to increase gamma activity will improve cognition.
Key facts
- Study ID
- NCT02468804
- Run by
- University of Colorado, Denver
- People needed
- 107
- Starts
- 2013-08-01
- Expected to finish
- 2016-11-01
- Last updated by the study team
- 2021-07-27
Who can join
Age: 45 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- We will recruit 60 PD patients through the University Colorado Hospital (UCH) Movement Disorders Clinic diagnosed with probable PD using United Kingdom (UK) Brain Bank Criteria.
- PD patients will be of mild to moderate severity based on the Hohn and Yahr scale (score of 3 or less in on medication state) and be on a stable dose of PD medications.
- Clinical severity will also be assessed using the Unified Parkinson Disease Rating Scale.
- We do not anticipate recruitment to be difficult as UCH Movement clinics see over 800 PD patients annually, the majority of whom are stage 3 or less.
- Controls will be approximately matched for age and gender as a group and recruited through clinic (spouses) and advertisements in the community.
You may not qualify if…
- Subjects will be excluded if they have significant depression (Beck Depression Inventory33 > 14)
- Dementia (Mini Mental State Examination34 < 26 or Frontal Assessment Battery35 < 14)
- Other neurological or psychiatric illness
- Significant history of head injury, significant systemic medical diseases (e.g. liver failure, kidney failure, poorly controlled diabetes)
- Deep Brain Stimulation (DBS)
- Cognitive enhancing medications (e.g. stimulants or acetylcholinesterase inhibitors) or contraindications to either TMS or MRI (pregnancy, pacemaker, unstable cardiac disease, skull lesion, claustrophobia, history of epilepsy or on medications known to lower seizure threshold).
Where it is running
- UC Denver Building 534 — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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