Study of HUCNS-SC Subretinal Transplantation in Subjects With GA of AMD

Stopped early · Phase 2

Conditions studied: Age-Related Macular Degeneration

In brief

A fellow eye controlled study of HUCNS-SC sub-retinal transplantation in subjects with bilateral GA AMD. All subjects will be assigned to HUCNS-SC transplantation.

Key facts

Study ID

NCT02467634

Run by

StemCells, Inc.

People needed

3

Starts

2015-06-01

Expected to finish

2016-05-01

Last updated by the study team

2016-06-02

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• GA associated with AMD in both eyes. Total area of GA determined by fundus autofluorescence.
• BCVA of 20/320 or better in each eye at screening assessment

You may not qualify if…

• Prior or concurrent choroidal neovascularization in either eye by clinical exam and/or fluorescein angiography as determined by the investigator or the reading center.
• Retinal or macular disease of any other cause in either eye.
• Diagnosis of glaucoma in either eye.
• Uncontrolled intraocular pressure in either eye
• Compromised renal function defined as eGFR <60mL/min and urine protein-to-creatinine ration >0.3 is spot urine collection.
• History of or active autoimmune disease.
• Previous organ, tissue or bone marrow transplantation.
• Seropositive for HIV, hepatitis B or C, or CMV IgM

Where it is running

• Retina Associates Southwest, PC — Tucson, Arizona, United States
• Retina Vitreous Associates Medical Group — Beverly Hills, California, United States
• Retinal Diagnostic Center — Campbell, California, United States
• Northern California Retina Vitreous Associates — Mountain View, California, United States
• Retina Research Institute of Texas — Palo Alto, California, United States
• Rush University Med Ctr. — Chicago, Illinois, United States
• William Beaumont Health System — Royal Oak, Michigan, United States
• New York Eye and Ear Infirmary — New York, New York, United States
• Retina Research Institute of Texas — Abilene, Texas, United States
• Retina Research Center — Austin, Texas, United States
• Retina Foundation of the Southwest — Dallas, Texas, United States
• University Of Utah / John A. Moran Eye Center — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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