Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia

Stopped early · Not applicable

Conditions studied: Intermittent Exotropia

In brief

To determine the effectiveness of alternate occlusion therapy for the treatment of IXT among patients aged 3 to \< 11 years old.

Key facts

Study ID: NCT02466659
Run by: Indiana University
People needed: 8
Starts: 2015-02-01
Expected to finish: 2016-12-01
Last updated by the study team: 2017-11-30

Who can join

Age: 3 and older, up to 11. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Intermittent exotropia (manifest deviation) meeting all of the following criteria:
Intermittent exotropia at distance OR constant exotropia at distance and either intermittent exotropia or exophoria at near
Exodeviation at least 15PD at distance OR near measured by prism and alternate cover test (PACT)
Exodeviation at least 10PD at distance measured by PACT
No previous surgical or non-surgical treatment for IXT (other than refractive correction)
Visual acuity in the worse eye 0.3 logMAR or better (20/40 on ATS HOTV or 70 letters on E-ETDRS) for children ≥ 3 years of age
No interocular difference of visual acuity more than 0.2 logMAR (2 lines on ATS HOTV or 10 letters on E-ETDRS) for children ≥ 7 years of age
Investigator not planning to initiate amblyopia treatment
No hyperopia greater than +3.50 D spherical equivalent in either eye
No myopia greater than -6.00 D spherical equivalent in either eye
No prior strabismus, intraocular, or refractive surgery
No abnormality of the cornea, lens, or central retina
Investigator willing to observe the IXT untreated for 3 years unless specific criteria for deterioration are met.

You may not qualify if…

Where it is running

Glick Eye Institute, Indiana University School of Medicine — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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