Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions
Completed · Not applicable
Conditions studied: Borderline Personality Disorders, Avoidant Personality Disorders
In brief
Borderline Personality Disorder (BPD), a prevalent psychiatric disorder found in approximately 2% to 6% of the population and 20% of hospitalized psychiatric patients, has proven quite treatment resistant. This study is designed to determine whether patients with BPD can be trained to improve their ability to regulate their emotions and whether this leads to changes in how their brans regulate emotion.
Key facts
- Study ID
- NCT02465697
- Run by
- Icahn School of Medicine at Mount Sinai
- People needed
- 169
- Starts
- 2011-09-01
- Expected to finish
- 2017-09-21
- Last updated by the study team
- 2017-10-31
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- BPD subjects 18 to 50 years old
- Meet criteria for DSM-IV Borderline Personality Disorder, including the DSM-IV criteria for affective instability (criterion #6), and not meet criteria for Schizotypal Personality Disorder (SPD) or AvPD.
- Subjects in the AvPD group meet DSM-IV criteria for AvPD and not for BPD or SPD.
- All subjects will be free of psychotropic medications for 2 weeks (6 weeks for fluoxetine).
- Subjects may be enrolled in psychotherapy
You may not qualify if…
- BPD and AvPD subjects will not meet DSM-IV criteria for past or present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance dependence, head trauma, CNS neurological disease, seizure disorder or current major depression.
- Substance abuse disorder in the prior 6 months
- Significant medical illness
- Pregnancy
- Metallic foreign-bodies that contraindicate MRI
Where it is running
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
Full record on ClinicalTrials.gov
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