Macronutrient Regulation of Ghrelin and Peptide YY
Completed · Not applicable
Conditions studied: Obesity, Prader Willi Syndrome
In brief
The hyperghrelinemia of children with PWS provides a unique model by which to explore the hormonal and metabolic effects of orexigenic hormones in normal and pathologic conditions. An important question to be addressed by this proposed research includes the macro-nutrient regulation of ghrelin and PYY in obese children and children with PWS. As ghrelin antagonists are considered potential future anti-obesity agents, it is essential to gain understanding of the developmental, nutritional and hormonal regulation of this important orexigenic hormone in children.
Key facts
- Study ID
- NCT02464514
- Run by
- Duke University
- People needed
- 28
- Starts
- 2004-01-01
- Expected to finish
- 2005-12-01
- Last updated by the study team
- 2015-08-10
Who can join
Age: 5 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of PWS confirmed by chromosome analysis (i.e. interstitial deletion of paternally-derived chromosome 15Q, uniparental maternal disomy or other chromosome 15 abnormalities) or normal control
- Subjects with simple obesity
- Ages 5 years to 17 years
- Written informed consent and assent obtained and willingness to comply with the study schedule and procedures.
- Free T4, TSH values in the normal range (either endogenous or with thyroxine replacement)
You may not qualify if…
- Patients with any other clinically significant disease that would have an impact on body composition including diabetes mellitus, chronic inflammatory bowel disease, chronic severe liver or kidney disease or neurologic disorders
- Concomitant use of an investigational drug in the past year
- Patients with an active malignancy
- Parent or legal guardian unable to provide informed consent.
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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