Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence

Completed · Not applicable

Conditions studied: Posttraumatic Stress Disorder, Substance Dependence

In brief

The purpose of the study is to determine whether a novel integrated cognitive-behavioral treatment for posttraumatic stress disorder (PTSD) and substance dependence (i.e., Treatment for Integrated Posttraumatic Stress and Substance use; TIPSS) is more effective than cognitive-behavioral treatment for substance dependence alone with regard to PTSD symptoms and substance use quantity and frequency.

Key facts

Study ID

NCT02461732

Run by

The University of Texas Health Science Center, Houston

People needed

60

Starts

2014-08-01

Expected to finish

2016-11-01

Last updated by the study team

2017-05-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65
• English language proficiency
• Current (past month) substance dependence, noting exclusions as delineated below
• History of trauma exposure, as per DSM-5 Criterion A1 definition
• Current (past month) PTSD symptoms: score of at least 25 on PCL-5 and/or at least 4 symptoms of moderate severity (scored 2 or higher) endorsed on CAPS-5
• Seeking treatment for trauma-related symptoms and substance dependence

You may not qualify if…

• Exclusive [only] nicotine dependence
• Alcohol dependence requiring detoxification
• Opiate dependence requiring detoxification
• Current or past bipolar I disorder
• Current or past major psychotic disorder
• Active (past 6 months) psychotic spectrum symptoms
• Major unstable medical conditions
• Current (past month) suicidal ideation with intent and/or plan
• Current (past month) homicidal ideation with intent and/or plan
• Inability to provide verbal/written consent

Where it is running

• University of Texas Health Science Center at Houston - Center for Neurobehavioral Research on Addiction — Houston, Texas, United States

Full record on ClinicalTrials.gov

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