Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
Running, not enrolling
Conditions studied: Tuberous Sclerosis, Autism Disorder, Intellectual Disability
In brief
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive of ASD and ID presence and severity in patients with TSC. In addition, this study will be establishing infrastructure for the collection and storage of human bio-specimens, including genetic material, from TSC patients and their family members with ASD.
Key facts
- Study ID
- NCT02461459
- Run by
- Boston Children's Hospital
- People needed
- 205
- Starts
- 2015-05-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Meets genetic or clinical diagnostic criteria for TSC (Tuberous Sclerosis), the latter based on current recommendations for diagnostic evaluation, such as physical exam, neuroimaging, and echocardiogram.
- Age criteria: over 18 months of age at time of enrollment.
- Is diagnosed or suspected to have ASD and/or ID.
- Primary communicative language is English
You may not qualify if…
- Has taken an investigational drug as part of another research study, within 30 days prior to study enrollment.
- For subjects involved in imaging biomarker assessment: contraindications to 3T MRI scanning, such as metal implants/non-compatible medical devices or medical conditions, including vagus nerve stimulator.
- For subjects involved in EEG/ERP biomarker assessment: contraindications to EEG/ERP, such as uncooperative or destructive behaviors preventing lead placement or capture by ERP/VEP equipment. Under age 2 or above age 11 at the time of enrollment.
- Unwilling or unable to comply with study procedures and assessments.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- University of California at Los Angeles — Los Angeles, California, United States
- Stanford University — Palo Alto, California, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- University of Texas at Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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