Fertility Assessment in Patients With Klinefelter Syndrome

Stopped early

Conditions studied: Klinefelter Syndrome

In brief

Klinefelter syndrome is characterized by primary testicular failure and progressive infertility. The objective of this study is to determine if sperm are present and can be observed in semen samples of adolescent and young adult Klinefelter patients and to determine whether the presence of sperm correlates with physical and/or clinically obtained hormone measures of pubertal development. This study was designed in order to answer the following questions: 1. Is it possible to retrieve sperm for cryopreservation from semen samples of adolescent and young adult Klinefelter patients? 2. Does the presence of sperm correlate with the physical and/or endocrine measures that are assessed during routine clinical evaluations of pubertal development in the KS patient population? 3. If sperm retrieval is possible, what is the optimal age at which sperm retrieval should be attempted?

Key facts

Study ID: NCT02461303
Run by: University of Pittsburgh
People needed: 6
Starts: 2016-01-07
Expected to finish: 2017-12-12
Last updated by the study team: 2018-07-24

Who can join

Age: 12 and older, up to 25. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

males between the ages of 12 and 25
diagnosed with mosaic or non-mosaic Klinefelter's Syndrome
having bilaterally descended testes
not having had a febrile illness within 3 months of enrollment.

You may not qualify if…

previous treated with gonadotoxic chemotherapeutic or radiation regimen.
psychological, psychiatric, or other conditions which prevent giving fully informed consent.

Where it is running

Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States
Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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