Brain Connectivity and Response to Tai Chi in Geriatric Depression

Completed · Not applicable

Conditions studied: Major Depressive Disorder

In brief

The purpose of this study is to evaluate the effects after up to 1 year of supervised weekly Tai-Chi-Chi versus Health Education and Wellness classes on reduction of depressive symptoms and improvement in resilience, health functioning, quality of life, cognition, sleep, fMRI neural correlates of working memory, and brain structure.

Key facts

Study ID

NCT02460666

Run by

University of California, Los Angeles

People needed

220

Starts

2016-01-01

Expected to finish

2020-12-01

Last updated by the study team

2021-07-16

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A 24-item Hamilton Rating Scale for Depression (HAMD) score greater than 14 consistent with moderate-severe depression.
• Mini-Mental State Exam (MMSE) score greater than 24.
• Sufficient English proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV.
• Capacity to provide informed consent.
• A stable form of treatment for at least 4 months.

You may not qualify if…

• Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
• Any disabilities preventing their participation in Tai-Chi Chih exercise (e.g. severe visual or hearing impairment)
• Insufficient English proficiency
• Diagnosis of dementia
• Mini Mental Health Examination score of 24 and below
• Effective antidepressant, psychotropic medications, or effective therapy
• Participation in a psychotherapy that involves cognitive training
• Do not meet criteria for moderate-severe depression with a 24-item Hamilton Rating Scale for Depression (HAMD) score less than 14

Where it is running

• UCLA Semel Institute — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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