Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation
Status unconfirmed · Not applicable
Conditions studied: Respiratory Insufficiency, Hypoxia
In brief
1. To determine the lowest nasal cannula flow rate in which upper airway deadspace is reduced. Hypothesis - The lowest flow rate of high flow nasal cannula (HFNC) will reduce upper airway (extrathoracic) deadspace and improve respiratory efficiency by reducing transcutaneous CO2 and/or lower respiratory rate. 2. To determine the lowest nasal cannula flow rate in which regional distribution (as defined by EIT) of ventilation changes. Hypothesis - Moderate to high flow rates will create positive pressure that leads to improved regional distribution of ventilation.
Key facts
- Study ID
- NCT02460653
- Run by
- Boston Children's Hospital
- People needed
- 40
- Starts
- 2015-05-01
- Expected to finish
- 2021-07-01
- Last updated by the study team
- 2019-06-04
Who can join
Age: 0 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All patients who are receiving HFNC for hypoxia
- Age: 1 day (> 38 weeks GA neonate or older) to 17 years.
You may not qualify if…
- i. Patients who have congenital heart defects. ii. Patient who the medical team feels may require urgent escalation of non-invasive therapy or imminent intubation.
- iii. Patients who are on FIO2 > 0.6 at the highest level of flow offered within the study.
- iv. Patients who are immunocompromised and/or status post bone marrow transplant v. Patients who are on vasoactive support to maintain blood pressure or heart rate vi. Patients with a known airway anomaly, e.g. Pierre-Robin, tracheomalacia. vii. Patients less than 38 weeks gestational age viii. Patients less than 3 kilograms ix. If the EIT band/electrodes are not able to be properly positioned on the chest due to size/weight limitations x. If the medical team feels that the patient is not appropriate to enroll in the study based on medical, social or emotional concerns
Where it is running
- Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
- Seattle Children's Hospital — Seattle, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.