Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive Supranuclear Palsy

Completed · Phase 1 · Has a placebo group

Conditions studied: Progressive Supranuclear Palsy

In brief

The purpose of this study is to evaluate the safety and tolerability of multiple ascending intravenous infusions of BMS-986168 and to assess the pharmacokinetics and immunogenicity of BIIB092, and pharmacodynamics of BIIB092 on cerebrospinal fluid (CSF) extracellular tau (eTau) concentrations in participants with Progressive Supranuclear Palsy.

Key facts

Study ID

NCT02460094

Run by

Biogen

People needed

48

Starts

2015-10-02

Expected to finish

2016-10-19

Last updated by the study team

2018-09-04

Who can join

Age: 41 and older, up to 86. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Probable or possible PSP defined as:
• at least a 12-month history of postural instability or falls during the first 3 years that symptoms are present
• a decreased downward saccade velocity at screening defined as observable eye movement deviation from the "main sequence" linear relationship between saccade amplitude and saccade velocity; or supranuclear ophthalmoplegia defined as 50% reduction in upward gaze or 30% reduction in downward gaze; and
• age at symptom onset of 40 to 85 years by history and current age between 41 and 86 years, inclusive, at the time of screening; and
• an akinetic-rigid syndrome with prominent axial rigidity.
• presence of symptoms for less than 5 years.
• Body weight range of ≥ 43 kg/95 lbs to ≤ 118 kg/260 lbs.
• Able to tolerate MRI.
• Able to perform all protocol-specified assessments and comply with the study visit schedule.
• Have reliable caregiver to accompany patient to all study visits. Caregiver must be able to read, understand, and speak local language fluently to ensure comprehension of informed consent and informant-based assessments of patient. Caregiver must also have frequent contact with patient (at least 3 hours per week at one time or at different times) and be willing to monitor the patient's health and concomitant medications throughout the study.
• Score ≥ 20 on the Mini Mental State Exam (MMSE) at screening.
• Patient must reside outside a skilled nursing facility or dementia care facility at the time of screening, and admission to such a facility is not planned. Residence in an assisted living facility is allowed.
• Ability to ambulate independently or with assistance defined as the ability to take at least 5 steps with a walker (guarding is allowed provided there is no contact) or the ability to take at least 5 steps without a walker or cane with the assistance of another person who can only have contact with one upper extremity.
• Stable on other chronic medications for at least 30 days prior to screening.
• Women of child bearing potential (WOCBP) and sexually active fertile men with partners who are WOCBP must use highly effective birth control.

You may not qualify if…

• Presence of other significant neurological or psychiatric disorders.
• History of or screening brain MRI scan indicative of significant abnormality.
• History of cancer within 5 years of screening with the exception of fully excised non-melanoma skin cancers or non-metastatic prostate cancer that has been stable for at least 6 months.
• History of clinically significant hematological, endocrine, cardiovascular, renal, hepatic, gastrointestinal, or neurological disease.
• Inability to be venipunctured and/or tolerate venous access.
• Contraindication to undergoing an LP.
• Recent drug or alcohol abuse as defined in DSM IV.
• Treatment with any investigational drugs (including placebo) or devices within 90 days prior to screening.
• Contraindication to the MRI examination for any reason
• History of a clinically significant medical condition that would interfere with the patient's ability to comply with study instructions, would place the patient at increased risk, or might confound the interpretation of the study results.
• History of allergy, hypersensitivity, or serious adverse reaction to monoclonal antibodies or related compounds or allergy to any of the components of the study drug

Where it is running

• The University of Alabama at Birmingham — Birmingham, Alabama, United States
• David Geffen School of Medicine at UCLA — Los Angeles, California, United States
• University of California San Diego — San Diego, California, United States
• University of California, San Francisco, Medical Center at Parnassus — San Francisco, California, United States
• Parkinsons Disease and Movement Disorders Center of Boca Raton — Boca Raton, Florida, United States
• University of Florida College of Medicine — Gainesville, Florida, United States
• University of South Florida — Tampa, Florida, United States
• The University of Chicago Department of Neurology — Chicago, Illinois, United States
• University of Minnesota Medical School — Minneapolis, Minnesota, United States
• Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
• Columbia University Medical Center — New York, New York, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• The University of Texas Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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