Compare Fentanyl Nasal Spray With Intravenous Opioids to Treat Severe Pain

Completed · Phase 4

Conditions studied: Advanced Cancers, Pain

In brief

The goal of this clinical research study is to compare fentanyl nasal spray with a standard drug given by vein (hydromorphone hydrochloride) to help reduce pain related to cancer in patients coming to the emergency department.

Key facts

Study ID

NCT02459964

Run by

M.D. Anderson Cancer Center

People needed

84

Starts

2015-09-14

Expected to finish

2020-06-21

Last updated by the study team

2021-06-16

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cancer patients with severe pain (i.e., >=7 on NRS, see Table 1) already on opioid therapy for one week or longer, at least 60 mg of oral morphine/day, 25 mcg of transdermal fentanyl/hour, 30 mg of oxycodone/day, 8 mg oral hydromorphone/day, 25 mg oral oxymorphone/day, or an equianalgesic dose of another opioid.
• Ability to give informed consent before any trial-related activities (Trial-related activities are any procedure that would not have been performed during normal management of the subject.)
• Ability and willingness to communicate the intensity of pain using NRS at the frequency dictated by the protocol

You may not qualify if…

• Patients with a history of chronic active hepatitis, cirrhosis or hepatic encephalopathy
• Inability to give informed consent
• Known or suspected hypersensitivity or intolerance to fentanyl or hydromorphone or excipients in the study medications
• Patients with sinusitis, obstruction of nasal passages, nasopharyngeal cancer, paranasal sinus malignancies, or any conditions in the nasopharyngeal anatomical area that may affect the absorption of fentanyl nasal spray.
• Females who are pregnant, breast-feeding or intending to become pregnant. This exclusion criterion will be assessed by questioning the patient about the pregnancy status, breast-feeding status, the intent to become pregnant, the menopausal status, and the date of the last menstrual period.
• Females of child-bearing potential, who are not using adequate contraceptive measures (including condoms, birth control pills, intrauterine devices, contraceptive implants, or other US FDA-approved contraceptives)
• Previous participation in randomization in this trial
• Has taken oral immediate release opioids within 4 hours prior to arrival.

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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