Effects of Varied Estrogen Doses on Endometrial Receptivity

Completed

Conditions studied: Luteal Phase Defect

In brief

This study will help determine the effect of varied estradiol levels on the uterine lining in healthy humans that are not undergoing a stimulated in vitro fertilization (IVF) cycle.

Key facts

Study ID

NCT02458404

Run by

Reproductive Medicine Associates of New Jersey

People needed

19

Starts

2015-03-01

Expected to finish

2019-06-01

Last updated by the study team

2019-11-07

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Regular menstrual cycles
• Age 18-50
• Normal Baseline ultrasound
• No intra-uterine procedures in prior 90 days

You may not qualify if…

• Any contraindications to undergoing estrogen stimulation of the endometrium
• Age ≥35 years and smoking ≥15 cigarettes per day
• Multiple risk factors for arterial cardiovascular disease (smoking, diabetes, and hypertension)
• Hypertension (systolic ≥140 mmHg or diastolic ≥90 mmHg)
• Venous thromboembolism (current or history of)
• Known thrombogenic mutations
• Known ischemic heart disease
• History of stroke
• Complicated valvular heart disease (pulmonary hypertension, risk for atrial fibrillation, history of subacute bacterial endocarditis)
• Systemic lupus erythematosus (positive or unknown antiphospholipid antibodies)
• Migraine with aura at any age
• Breast cancer
• Cirrhosis
• Hepatocellular adenoma or malignant hepatoma
• History of undiagnosed abnormal uterine bleeding.
• Allergic reaction to any study drug
• Known pregnancy or delivery within the past 6 months
• Breastfeeding
• Obesity >35 kg/m2

Where it is running

• Reproductive Medicine Associates of New Jersey — Basking Ridge, New Jersey, United States

Full record on ClinicalTrials.gov

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