Antibiotic Dosing in Pediatric Intensive Care

Recruiting now

Conditions studied: Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Vancomycin, Teicoplanin, Meropenem, Ciprofloxacin, Amikacin

In brief

Pharmacokinetics of antibiotics in critically ill neonates, infants and children

Key facts

Study ID

NCT02456974

Run by

University Hospital, Ghent

People needed

640

Starts

2012-05-01

Expected to finish

2027-09-01

Last updated by the study team

2026-01-16

Who can join

Age: 0 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients admitted to the pediatric intensive care unit
• patient age/weight : 1,8 kg-15 years
• patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines
• intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)

You may not qualify if…

• no catheter in place for blood sampling
• absence of parental/patient consent
• known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides
• extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )

Where it is running

• Ghent University Hospital, Hospital Pharmacy — Ghent, Belgium (enrolling)

Full record on ClinicalTrials.gov

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