Expandability of Aging Adipose Tissue

Completed · Not applicable

Conditions studied: Aging, Obesity

In brief

The purpose of this pilot study is to determine whether adipose tissue loses some of its ability to expand in response to overfeeding in older compared to younger men. The investigators hypothesize that the adipose tissue response to overfeeding may be weakened in older when compared to younger men, thereby leading to worsened ectopic storage depots for older men.

Key facts

Study ID

NCT02456870

Run by

University of Colorado, Denver

People needed

20

Starts

2015-06-01

Expected to finish

2018-12-01

Last updated by the study team

2019-06-13

Who can join

Age: 25 and older, up to 75. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Men
• Aged 25-40y OR 55-75y
• BMI 28-35 kg/m2
• Weight stable (±2kg over past 3 mo)
• Sedentary to moderately active (<3 d/wk of exercise lasting >20min)
• Non-smokers (never used or quit >7yrs prior)

You may not qualify if…

• Women
• Currently using hormones, glucose or lipid lowering medication
• Engaged in exercise or diet program
• Currently gaining or losing weight or using weight loss drugs
• Diabetes mellitus (diagnosis, treatment, FBG ≥126 mg/dL)
• Uncontrolled metabolic disorders (e.g., thyroid)

Where it is running

• Univeristy of Colorado, Anschutz Medical Campus — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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