Neuronal Effects of Exercise in Schizophrenia

Recruiting now · Not applicable

Conditions studied: Schizophrenia

In brief

This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.

Key facts

Study ID

NCT02455193

Run by

University of Colorado, Denver

People needed

140

Starts

2014-08-01

Expected to finish

2025-09-01

Last updated by the study team

2025-04-22

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of schizophrenia or schizoaffective disorder
• Between 21 and 70 years of age
• Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications
• Weight stable within 5 percent for the last 6 months

You may not qualify if…

• Pregnancy
• Substance abuse
• Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia)
• MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)

Where it is running

• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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