Effects of a Bicycling Intervention on Cognitive Skills and Cardiovascular Health

Completed · Not applicable

Conditions studied: Sedentary Lifestyle

In brief

Although exercise is known to delay cognitive decline and decrease our risk of Alzheimer's Disease, there is a lack of understanding of how exercise protects the aging brain. The proposed research takes a novel approach to this problem by testing the concept that there are acute, direct effects of exercise in the same brain regions that are affected by chronic exercise training. If the investigators are successful, the acute paradigm will allow us to determine the critical exercise parameters that modulate brain function in humans using only a single exercise dose.

Key facts

Study ID

NCT02453178

Run by

University of Iowa

People needed

33

Starts

2015-07-01

Expected to finish

2018-01-01

Last updated by the study team

2018-01-30

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Eligible to participate in an aerobic exercise intervention based on the Physical Activity Readiness Questionnaire, and corrected vision of 20/40.
• Because our older adult sample is over the age of 40, we will also require completion of a detailed health history questionnaire and further eligibility for the exercise intervention will be determined following approval from a physician that monitored electrocardiography (ECG) response during a maximal aerobic fitness test that is part of the second study visit described below.

You may not qualify if…

• Not between the ages of 60 and 80 years old
• Not fluent in English
• Score < 26 (out of 30) on the Montreal Cognitive Assessment (MoCA)
• Inability to comply with experimental instructions
• Qualify as "high risk" for acute cardiovascular event by the published standards of the American College of Sports Medicine
• Left-handed
• Previous diagnosis of neurological, metabolic, or psychiatric condition, and no previous brain injury associated with loss of consciousness
• Inability to complete an MRI

Where it is running

• HBC Lab — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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