Corticospinal Function After Spinal Cord Injury
Completed · Not applicable · Has a placebo group
Conditions studied: Spinal Cord Injury
In brief
The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal cord injury (SCI). The investigator proposes to use modern electrophysiological methods to enhance the efficacy of residual corticospinal connections. Defining the neural basis by which corticospinal volleys generate muscle responses will provide crucial information required to maximize residual motor output. The investigator's specific goals are to: 1) determine the temporal and spatial organization of corticospinal volleys and motor cortical representations of upper-limb muscles after incomplete cervical SCI and 2) develop methodologies to promote recovery of function. The investigator's focus on reach and grasp movements because of their importance in daily life activities.
Key facts
- Study ID
- NCT02451683
- Run by
- Shirley Ryan AbilityLab
- People needed
- 120
- Starts
- 2020-10-12
- Expected to finish
- 2026-01-30
- Last updated by the study team
- 2026-03-03
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Inclusion criteria for individuals with SCI:
- Male and females between 18-85 years,
- Chronic SCI (≥ 6 months post injury),
- Cervical injury at C8 or above,
- Intact or impaired but not absent innervations in dermatomes C6, C7, and C8 using the American Spinal Injury Association sensory scores, and
- Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk
- Inclusion criteria for healthy controls:
- Male and females between 18-85 years,
- Right handed,
- Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk
You may not qualify if…
- Exclusion criteria for individuals with SCI and Healthy Controls:
- Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
- Any debilitating disease prior to the SCI that caused exercise intolerance
- Premorbid, ongoing major depression or psychosis, altered cognitive status
- History of head injury or stroke
- Pacemaker
- Metal plate in skull
- History of seizures
- Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants
- Pregnant females
- Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk.
- History of brain tumor and or brain infection
Where it is running
- Shirley Ryan AbilityLab — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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