Treatment for Nicotine Addiction in Women

Completed · Not applicable · Has a placebo group

Conditions studied: Nicotine Dependence

In brief

The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.

Key facts

Study ID

NCT02448654

Run by

Yale University

People needed

36

Starts

2015-10-23

Expected to finish

2019-06-30

Last updated by the study team

2020-11-24

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Must be 18yrs to 45yr old woman, read and write in English.
• Must smoke at least 5 or more cigarettes a day
• FTND score at least 4 or higher
• A CO reading of 10 or higher during screening
• Must be in good health as verified by medical history, screening exam, screen laboratory tests.

You may not qualify if…

• Excluded if using psychotropic medications, have contraindications to tolcapone use (e.g.. liver problems, allergy to tolcapone, history of no traumatic rhabdomyolysis or hyperpyrexia, confusion possibly related to medication), have other substance use disorder, are pregnant or breast feeding, have a current psychotic disorder, bipolar disorder, homicidal or suicidal ideation, have current (past month) substance use disorder, other than nicotine dependence, or are unable to fulfill the scheduled visits and procedures.

Where it is running

• Veterans Administration Hospital — West Haven, Connecticut, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.