Safety and Efficacy of Etrasimod (APD334) in Patients With Ulcerative Colitis

Completed · Phase 2 · Has a placebo group

Conditions studied: Ulcerative Colitis

In brief

The purpose of this study is to determine whether etrasimod is a safe and effective treatment for ulcerative colitis.

Key facts

Study ID

NCT02447302

Run by

Arena Pharmaceuticals

People needed

156

Starts

2015-10-15

Expected to finish

2018-02-14

Last updated by the study team

2021-04-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Moderately to severely active ulcerative colitis defined as a 3-component Mayo Clinic score
• Evidence of colonic ulcerative colitis activity on endoscopy

You may not qualify if…

• Within 30 days prior to randomization, receipt of any of the following for the treatment of underlying disease: Non-biologic therapies (eg, cyclosporine, tacrolimus, tofacitinib, thalidomide), a non-biologic investigational therapy or an approved non-biologic therapy in an investigational protocol
• Within 60 days prior to randomization, receipt of any of the following: Infliximab, adalimumab, golimumab, certolizumab, vedolizumab, any other investigational or approved biologic agent
• Any prior exposure to natalizumab, efalizumab, or rituximab

Where it is running

• Arena 1133 — Dothan, Alabama, United States
• Arena 1143 — Thousand Oaks, California, United States
• Arena 1107 — Hollywood, Florida, United States
• Arena 1138 — Miami, Florida, United States
• Arena 1123 — Naples, Florida, United States
• Arena 1141 — Orlando, Florida, United States
• Arena 1106 — Port Orange, Florida, United States
• Arena 1137 — Sweetwater, Florida, United States
• Arena 1131 — Chicago, Illinois, United States
• Arena 1139 — Hoffman Estates, Illinois, United States
• Arena 1127 — Urbana, Illinois, United States
• Arena 1142 — Traverse City, Michigan, United States
• Arena 1111 — Troy, Michigan, United States
• Arena 1109 — Great Neck, New York, United States
• Arena 1114 — Rochester, New York, United States
• Arena 1118 — Raleigh, North Carolina, United States
• Arena 1112 — Cincinnati, Ohio, United States
• Arena 1117 — Pittsburgh, Pennsylvania, United States
• Arena 1105 — Germantown, Tennessee, United States
• Arena 1102 — Hermitage, Tennessee, United States
• Arena 1136 — DeSoto, Texas, United States
• Arena 1121 — Houston, Texas, United States
• Arena 1116 — Temple, Texas, United States
• Arena 1103 — Ogden, Utah, United States
• Arena 1119 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.