Study of Efficacy and Safety of CTL019 in Adult DLBCL Patients

Completed · Phase 2

Conditions studied: Diffuse Large B-cell Lymphoma (DLBCL)

In brief

This is a multi-center, phase II study to determine the efficacy and safety of CTL019 in adult patients with relapsed or refractory DLBCL.

Key facts

Study ID

NCT02445248

Run by

Novartis Pharmaceuticals

People needed

115

Starts

2015-07-29

Expected to finish

2022-12-22

Last updated by the study team

2024-04-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent must be obtained prior to any screening procedures
• Histologically confirmed DLBCL at last relapse(by central pathology review before enrolment.
• .- Relapsed or refractory disease after ≥2 lines of chemotherapy including rituximab and anthracycline and either having failed autologous Hematopoietic stem cell transplantation (ASCT), or being ineligible for or not consenting to ASCT
• Measurable disease at time of enrollment
• Life expectancy ≥12 weeks
• Eastern Cooperative Oncology Group (ECOG) performance status that is either 0 or 1 at screening
• Adequate organ function:
• Renal function defined as:
• A serum creatinine of ≤1.5 x Upper Limit of Normal ULN OR
• Estimated Glomerular Filtration Rate (eGFR) ≥ 60 mL/min/1.73 m\^2
• Liver function defined as:
• Alanine Aminotransferase (ALT) ≤ 5 times the Upper Limit of Normal (ULN) for age
• Bilirubin ≤ 2.0 mg/dl with the exception of patients with Gilbert-Meulengracht syndrome; patients with Gilbert-Meulengracht syndrome may be included if their total bilirubin is ≤ 3.0 x ULN and direct bilirubin ≤ 1.5 x ULN
• Must have a minimum level of pulmonary reserve defined as ≤ Grade 1 dyspnea and pulse oxygenation > 91% on room air
• Hemodynamically stable and Left Ventricle Ejection Fraction (LVEF) ≥ 45% confirmed by echocardiogram or Multigated Radionuclide Angiography (MUGA)
• Adequate bone marrow reserve without transfusions defined as:
• Absolute neutrophil count (ANC) > 1.000/mm\^3
• Absolute lymphocyte count (ALC) ≥ 300/mm\^3 and absolute number of CD3+ T cells > 150/mm\^3
• Platelets ≥ 50.000//mm\^3
• Hemoglobin > 8.0 g/dl
• Must have an apheresis product of non-mobilized cells accepted for manufacturing
• Women of child-bearing potential (defined as all women physiologically capable of becoming pregnant) and all male participants must agree to use highly effective methods of contraception for at least 12 months following CTL019 infusion and until CAR T cells are no longer present by PCR on two consecutive tests

You may not qualify if…

• Prior treatment with any prior anti-CD19/anti-CD3 therapy, or any other anti-CD19 therapy
• Treatment with any prior gene therapy product
• Active Central Nervous System (CNS) involvement by malignancy
• Prior allogeneic HSCT
• Eligible for and consenting to HSCT
• Chemotherapy other than lymphodepleting chemotherapy within 2 weeks of infusion
• Investigational medicinal product within the last 30 days prior to screening
• The following medications are excluded:
• Steroids: Therapeutic doses of steroids must be stopped >72 hours prior to leukapheresis and >72 hours prior to CTL019 infusion. However, the following physiological replacement doses of steroids are allowed: < 12 mg/m\^2/day hydrocortisone or equivalent
• Immunosuppression: Any other immunosuppressive medication must be stopped ≥2 weeks prior to leukapheresis and ≥ 2 weeks prior to CTL019 infusion. This could include check point inhibitors (monoclonal antibodies and small molecule modulators)
• Antiproliferative therapies other than lymphodepleting chemotherapy within two weeks of leukapheresis and 2 weeks prior to infusion
• Short acting drugs used to treat leukemia or lymphoma (e.g. tyrosine kinase inhibitors, and hydroxyurea) must be stopped > 72 hour prior to leukapheresis and > 72 hours prior to CTL019 infusion
• Other cytotoxic drugs, including low dose daily or weekly maintenance chemotherapy, must not be given within 2 weeks prior to leukapheresis and within 2 weeks prior to CTL019 infusion
• Fludarabine may be associated with prolonged lymphopenia. This should be taken into consideration when evaluating the optimal timing for leukapheresis collection.
• Antibody use including anti-CD20 therapy within 4 weeks prior to infusion or 5 half-lives of the respected antibody, whichever is longer
• CNS disease prophylaxis must be stopped > 1 week prior to CTL019 infusion (e.g. intrathecal methotrexate)
• Prior radiation therapy within 2 weeks of infusion
• Active replication of or prior infection with hepatitis B or active hepatitis C( HCV RNA positive )
• HIV positive patients
• Uncontrolled acute life threatening bacterial, viral or fungal infection (e.g. blood culture positive ≤ 72 hours prior to infusion)
• Unstable angina and/or myocardial infarction within 6 months prior to screening
• Previous or concurrent malignancy with the following exceptions:
• Adequately treated basal cell or squamous cell carcinoma (adequate wound healing is required prior to study entry)
• In situ carcinoma of the cervix or breast, treated curatively and without evidence of recurrence for at least 3 years prior to the study
• A primary malignancy which has been completely resected and in complete remission for ≥ 5 years

Where it is running

• UCSF Medical Center . — San Francisco, California, United States
• Emory University School of Medicine/Winship Cancer Institute SC CTL019 — Atlanta, Georgia, United States
• University of Chicago Medical Center Hematology and Oncology SC - CTL019B2207J — Chicago, Illinois, United States
• University of Kansas Cancer Center SC - CTL019C2201 — Westwood, Kansas, United States
• Sidney Kimmel Comprehensive Cancer Center SC-2 — Baltimore, Maryland, United States
• Uni of Michigan Health System SC CTL019 — Ann Arbor, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Weill Cornell Medical College — New York, New York, United States
• The Ohio State University James Cancer Hospital & — Columbus, Ohio, United States
• Oregon Health Sciences University Oregon Health & Sci Uni — Portland, Oregon, United States
• University of Pennsylvania Perelman School of Medicine — Philadelphia, Pennsylvania, United States
• MD Anderson Cancer Center SC — Houston, Texas, United States
• Novartis Investigative Site — Melbourne, Victoria, Australia
• Novartis Investigative Site — Camperdown, Australia
• Novartis Investigative Site — Vienna, Austria
• Novartis Investigative Site — Hamilton, Ontario, Canada
• Novartis Investigative Site — Montreal, Quebec, Canada
• Novartis Investigative Site — Pierre-Bénite, France
• Novartis Investigative Site — Cologne, North Rhine-Westphalia, Germany
• Novartis Investigative Site — Würzburg, Germany
• Novartis Investigative Site — Milan, MI, Italy
• Novartis Investigative Site — Fukuoka, Fukuoka, Japan
• Novartis Investigative Site — Sapporo, Hokkaido, Japan
• Novartis Investigative Site — Chuo Ku, Tokyo, Japan
• Novartis Investigative Site — Amsterdam, Netherlands

Full record on ClinicalTrials.gov

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