Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease

Stopped early

Conditions studied: Sickle Cell Anemia

In brief

Patients with sickle cell anemia (SCA) are at an increased risk for damage to brain tissue due to their disease. The investigators are interested in how blood flow and cerebral inflammation are different in SCA patients and how that affects brain tissue- the investigators will use a relatively new set of dynamic MRI techniques to evaluate these parameters. The investigators will image participants with both SCA and matched controls with non-invasive MRI.

Key facts

Study ID

NCT02445144

Run by

Albert Einstein College of Medicine

People needed

26

Starts

2014-11-01

Expected to finish

2020-05-04

Last updated by the study team

2020-12-14

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patient with HbSS/HbSB0,
• age between 18 and 55 years or age/gender/race/education matched peer

You may not qualify if…

• Previous history of a stroke/transient ischemic attack,
• neurosurgery,
• head trauma,
• seizures,
• pulmonary embolism,
• deep-vein thrombosis,
• bleeding/clotting disorders,
• current or previous use of anticoagulation medications

Where it is running

• Albert Einstein College of Medicine — The Bronx, New York, United States
• Montefiore Medical Center (Einstein) — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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